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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)


Operational intricacies of sequencing-based surveillance in developing countries
Jimmy T. Efird
Annals of Translational Medicine
Mesenchymal stem cells: an early yet promising prospect for Asthma
Mariela Villarreal, Alvaro Moreira
Annals of Translational Medicine
Shining a light on foveal development after congenital cataract surgery
Annegret Dahlmann-Noor, Maryse Bailly
Annals of Translational Medicine
Polydeoxyribonucleotide injection in muscle atrophy/immobilization: does that ring a bell?
Wei-Ting Wu, Ke-Vin Chang, Levent Özçakar
Annals of Translational Medicine
Next steps in precision approaches for asthma-proteomics and asthma endotypes
Allan R. Brasier
Annals of Translational Medicine
Future directions in asthma pharmacogenomics
Scott T. Weiss
Annals of Translational Medicine

Original Article

Nicotinic acid supplementation contributes to the amelioration of Alzheimer’s disease in mouse models
Zhigang Wang, Zhenyou Zou, Qinghua Li
Annals of Translational Medicine
Pre-stroke dementia and in-hospital outcomes in the Chinese Stroke Center Alliance
Chelsea Liu, Hong-Qiu Gu, Xin Yang, Chun-Juan Wang, Xia Meng, Kai-Xuan Yang, Yun-Yun Xiong, Xing-Quan Zhao, Yi-Long Wang, Li-Ping Liu, Yong-Jun Wang, Zi-Xiao Li
Annals of Translational Medicine
Exploration of immune infiltration and feature genes in viral hepatitis-associated liver fibrosis using transcriptome data
Jiali Pan, Yu Tian, Fengling Hu, Jinghang Xu, Ning Tan, Yifan Han, Qian Kang, Hongyu Chen, Yuqing Yang, Xiaoyuan Xu
Annals of Translational Medicine
Identification of hub genes and infiltrating immune cells in skeletal muscle in obesity
Shuoshuo Jin, Jinya Huang, Kuangyang Chen, Xuanchun Wang
Annals of Translational Medicine
Smoke analysis of a new surgical system that applies low-temperature plasma
Boya Zhang, Qingyu Guan, Yunsheng Zhu, Jingjin Zhu, Xiaohan Liu, Shuaiqi Li, Rungong Yang, Xiru Li
Annals of Translational Medicine
Causal effects of serum sex hormone binding protein levels on the risk of amyotrophic lateral sclerosis: a mendelian randomization study
Ya-Nan Ou, Liu Yang, Bang-Sheng Wu, Lan Tan, Jin-Tai Yu
Annals of Translational Medicine
High expression of the ANXA3 gene promotes immune infiltration and improves tumor prognosis in ovarian serous carcinoma using bioinformatics analyses
De-Qiang Li, Mao Lin, Zeinab Abdelrahman
Annals of Translational Medicine
Correlation between gut bacteria Phascolarctobacterium and exogenous metabolite α-linolenic acid in T2DM: a case-control study
Weidong Li, Lisha Li, Fujie Yang, Qiongying Hu, Daqian Xiong
Annals of Translational Medicine
Identifying and validating key genes mediating intracranial aneurysm rupture using weighted correlation network analysis and exploration of personalized treatment
Ji Wu, Zhi-Jun Chen, Jing Liang, Chang-Sheng Lai, Xue-Yu Li, Zhao-Jian Yang
Annals of Translational Medicine
Bergenin inhibits palmitic acid-induced pancreatic β-cell inflammatory death via regulating NLRP3 inflammasome activation
Donghong Lei, Yanru Sun, Jie Liu, Jianxiu Chi
Annals of Translational Medicine
Identification and validation of a 9-gene signature for the prognosis of ovarian cancer by integrated bioinformatical analysis
Siping Chen, Man Yang, Haikun Yang, Qiaofei Tang, Chunming Gu, Weifeng Wei
Annals of Translational Medicine
Development and validation of the diagnostic accuracy of artificial intelligence-assisted ultrasound in the classification of splenic trauma
Xue Jiang, Yukun Luo, Xuelei He, Kun Wang, Wenjing Song, Qinggui Ye, Lei Feng, Wei Wang, Xiaojuan Hu, Hua Li
Annals of Translational Medicine
Entity relation extraction in the medical domain: based on data augmentation
Anli Wang, Linyi Li, Xuehong Wu, Jianping Zhu, Shanshan Yu, Xi Chen, Jianhua Li, Hongtao Zhu
Annals of Translational Medicine
Lipidomics reveals significant alterations associated with exclusive enteral nutrition treatment in adult patients with active Crohn’s disease
Qingfan Yang, Zicheng Huang, Na Diao, Jian Tang, Xia Zhu, Qin Guo, Kang Chao, Xiang Gao
Annals of Translational Medicine
Retrospective comparative cohort study of neovagina creation by modified Vecchietti-laparoendoscopic single-site surgery for Mayer-Rokitansky-Küster-Hauser syndrome
Chao Zhang, Fan Zhang, Xiu Wang, Shuncang Zhang
Annals of Translational Medicine
A virus preservation solution that inactivates the virus while maintaining the virus particle intact
Yuesong Weng, Jiefeng Zhou, Yubo Shi
Annals of Translational Medicine
Role of reactive oxygen species in high concentration glucose-induced growth inhibition of human peritoneal mesothelial cells
Nan Zhu, Yunhai Tang, Weijie Yuan, Zhihuan Tang
Annals of Translational Medicine
Characteristics of pre-sensitization-related acute antibody-mediated rejection in a rat model of orthotopic liver transplantation
Yuanyi Mang, Shengning Zhang, Jiaojiao Zhao, Jianghua Ran, Yingpeng Zhao, Laibang Li, Yang Gao, Wang Li, Guoyu Chen, Jun Ma, Li Li, Fukai Bao
Annals of Translational Medicine
Artificial intelligence scale-invariant feature transform algorithm-based system to improve the calculation accuracy of Ki-67 index in invasive breast cancer: a multicenter retrospective study
Ning Xie, Haoyu Zhou, Li Yu, Shaobing Huang, Can Tian, Keyu Li, Yi Jiang, Zhe-Yu Hu, Quchang Ouyang
Annals of Translational Medicine
Clinical evaluation of corrective effect of infraorbital depression by fat granule auto-transplantation via oral mucosa incision
Fangfang Guo, Jialin Song, Zexin Chen, Xinyang Yu, Lu Wang
Annals of Translational Medicine
Effect of roxadustat on serum metabolome and lipidome in patients with end-stage renal disease and erythropoiesis-stimulating agent resistance
Lichao Wang, Yulin Wu, Yongjiang Li, Lianlian You, Xinyu Liu, Zhihong Wang, Jia Xiao, Shuang Zhang, Tianrun Xu, Xiaolin Wang, Qi Li, Chunxiu Hu, Guowang Xu, Shuxin Liu
Annals of Translational Medicine
A retrospective cohort study of polatuzumab vedotin combined with immunochemotherapy in Chinese patients with relapse/refractory diffuse large B cell lymphoma
Yanyan Liu, Zhijun Wuxiao, Fancong Kong, Jifeng Feng, Jianqiu Wu, Zhihua Yao, Weilun Zhou, Fei Li
Annals of Translational Medicine
The clinical efficacy and safety of double reverse traction repositor and traction table in the reduction of unstable intertrochanteric fractures in elderly patients: a retrospective comparative study
Faqi Cao, Xudong Xie, Yiqiang Hu, Wu Zhou, Bobin Mi, Mengfei Liu, Guohui Liu
Annals of Translational Medicine

Review Article

A narrative review on the association of high intraocular pressure and glaucoma in patients with retinal vein occlusion
Sayena Jabbehdari, Ghasem Yazdanpanah, Louis B. Cantor, Amir Reza Hajrasouliha
Annals of Translational Medicine

Insights From the Reporting Guidelines1

Prof. Karin Hannes: COREQ (Consolidated Criteria for Reporting Qualitative Studies)
Kathy J. Du, Grace S. Li, Kaiping Zhang, Yao Lin, Fanghui Yang, Karin Hannes
Annals of Translational Medicine

Editorial Commentary

Tumor heterogeneity and the dilemma of antioxidant therapies in cancer
Heloisa Sobreiro Selistre-de-Araujo, Bianca Cruz Pachane, Wanessa Fernanda Altei
Annals of Translational Medicine


1. The series “Insights from the Reporting Guidelines” was commissioned by the editorial office, Annals of Translational Medicine without any funding or sponsorship.

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis
Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro
Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population
Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur
Probiotics for prevention of urinary stones
John C. Lieske
Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia
Julie L. Mitchell, Thomas M. Yankee
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers
Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review
Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
Genetics and epigenetic factors of Wilson disease
Valentina Medici, Janine M. LaSalle
Ventilator-induced lung injury and lung mechanics
Jason H. T. Bates, Bradford J. Smith
Precision oncology in liver cancer
Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation
Tara R. Semenkovich, Bryan F. Meyers
Inhalation therapies in acute respiratory distress syndrome
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay
The female urinary microbiota, urinary health and common urinary disorders
Linda Brubaker, Alan J. Wolfe
The association between bacteria and urinary stones
Andrew L. Schwaderer, Alan J. Wolfe
PDX1 associated therapy in translational medicine
Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi
Biomarkers of risk to develop lung cancer in the new screening era
Thomas Atwater, Pierre P. Massion
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig


Translating L-2-HG to kidney cancer at the bench and bedside
Omran Abu Aboud, Robert H. Weiss
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease
Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross
Dasatinib in breast cancer: Src-ing for response in all the wrong kinases
Laura C. Kennedy, Vijayakrishna Gadi
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Exclusively Misook Tunic NWT S
Xu Han, Marvin T. Nieman
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy
Theresa L. Whiteside
Evolving treatment options for valve and aortic disease with bicuspid aortic valve
Nicholas S. Burris, Michael D. Hope
Exosomes may play a crucial role in HIV dendritic cell immunotherapy
Benjamin Wolfson, Justine E. Yu, Qun Zhou
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
It takes time to tune
Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams
Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery
Ezekiel Maloney, Joo Ha Hwang
Re-assessing stem cells in the stomach—one story two tales
Ming Jiang, Jianwen Que
Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
Theresa L. Whiteside
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence
Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Re-assessing the role of non-fasting lipids; a change in perspective
Zareen Farukhi, Samia Mora
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Anoma Nellore, Troy D. Randall
A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases
Jonathan E. Phillips, Richard H. Gomer
Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy
Qiongling Wang, Xander H. T. Wehrens
The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy
Ziheng Xu, Daniel J. Klionsky
Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Nike Sleek Modern Leather Belt SILVER
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation
Austin John Barrett, Catherine M. Bollard
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Level 99 Anthropologie Linen Tencel Blue Pants sz 10
Vibhu Parcha, Pankaj Arora
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment
Alex B. Blair, Vincent P. Groot, Jin He
Nephron repair: powered by anaerobic energy metabolism
Brooke E. Chambers, Rebecca A. Wingert
Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?
Andre P. Fay, Emmanuel S. Antonarakis
Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system
Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer
Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement
Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder
Melanie L. Bell
Low levels of interleukin-10 in patients with transfusion-related acute lung injury
Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple
Circulating CD40 autoantibody and suPAR synergy drives glomerular injury
Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser
Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs
Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review
He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng
Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report
Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng
Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma
Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease
Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng


Vinculin at the heart of aging
William H. Bradford, Jeffrey H. Omens, Farah Sheikh
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Ebrahim Afshinnekoo, Christopher E. Mason
Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors
Alexander D. Liddle
A sensible approach to targeting STAT3-mediated transcription
Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis
Circulating fibrocytes serve as a marker for clinical diagnosis
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
Collagen and fibronectin: threads linking obesity and breast cancer
Lesley G. Ellies
Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit
Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes
Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Andrew C. McKown, Lorraine B. Ware
TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis
Dragana Kopanja, Pradip Raychaudhuri
Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
Significance of microRNA-based biomarkers for pancreatic cancer
Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Health Service and Policy Research

Health Services & Policy Research in translational medicine
Nengliang (Aaron) Yao


Circulating free DNA in the management of breast cancer
Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity
Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson
The real difficulty in improving concordance of clinical practice with guidelines
Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness
Hye-Min Jeon, Jeongwu Lee
Effective implementation of novel MET pharmacodynamic assays in translational studies
Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma
Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights
Michele Carbone, Haining Yang
Environmental asbestos exposure and risk of mesothelioma
Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage
Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics
Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation
Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Original Article

Review Article

Editorial Commentary

iMDT Corner